Abstract
Objectives
To evaluate for the first time the performance of a deep learning method based on no-new-Net for fully automated segmentation and volumetric measurements of intracerebral hemorrhage (ICH), intraventricular extension of intracerebral hemorrhage (IVH), and perihematomal edema (PHE) in primary ICH on CT.
Methods
Three hundred and eighty primary ICH patients who underwent CT at hospital arrival were divided into a training cohort (n = 300) and a validation cohort (n = 80). An independent cohort with 80 patients was used for testing. Ground truth (segmentation masks) was manually generated by radiologists. Model performance on lesion segmentation and volumetric measurement of ICH, IVH, and PHE were evaluated by comparing the model results with the segmentations performed by radiologists.
Results
In the test cohort, the Dice scores of lesion segmentation were 0.92, 0.79, and 0.71 for ICH, IVH, and PHE, respectively. The sensitivities were 0.93 for ICH, 0.88 for IVH, and 0.81 for PHE. The positive predictive values were 0.92, 0.76, and 0.69 for ICH, IVH, and PHE, respectively. Excellent concordance (concordance correlation coefficients [CCCs] ≥ 0.98) of ICH and IVH and good concordance of PHE (CCCs ≥ 0.92) were demonstrated between manually and automatically measured volumes. The model took approximately 15 s to provide automatic segmentation and volume analysis for each patient.
Conclusion
Our model demonstrates good reliability for automatic segmentation and volume measurement of ICH, IVH, and PHE in primary ICH, which can be useful to reduce the effort and time of doctors to calculate volumes of ICH, IVH, and PHE.
Key Points
• Deep learning algorithms can provide automatic and reliable assessment of intracerebral hemorrhage, intraventricular hemorrhage, and perihematomal edema on CT.
• Non-contrast CT-based deep learning method can be helpful to provide efficient and accurate measurements of ICH, IVH, and PHE in primary ICH patients, thereby reducing the effort and time of doctors to segment and calculate volumes of ICH, IVH, and PHE in primary ICH patients.
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Abbreviations
- CCCs:
-
Concordance correlation coefficients
- GCS:
-
Glasgow Coma Scale
- ICH:
-
Intracerebral hemorrhage
- IVH:
-
Intraventricular extension of intracerebral hemorrhage
- PHE:
-
Perihematomal edema
- PPV:
-
Positive predictive value
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Funding
This study has received funding from Shanghai Municipal Health Commission (grant number 2019SY061).
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The scientific guarantor of this publication is Zhenwei Yao.
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The authors of this manuscript declare relationships with the following company: Ping An Technology (Shenzhen) Co., Ltd.
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Zhao, X., Chen, K., Wu, G. et al. Deep learning shows good reliability for automatic segmentation and volume measurement of brain hemorrhage, intraventricular extension, and peripheral edema. Eur Radiol 31, 5012–5020 (2021). https://doi.org/10.1007/s00330-020-07558-2
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DOI: https://doi.org/10.1007/s00330-020-07558-2